1 Changes in Accounting Policies and Estimates

As of June 1, 2010, the Company estimates that certain success criteria for a cooperation are met earlier than planned. This change in accounting estimate is applied prospectively and had a financial impact of € 0.2 million (additional revenues) for the first six months of 2010.

The accounting policies applied for the financial statements as of December 31, 2009, have been used throughout the first six months of 2010.