Glossary

  1. A

    Antigen
    Foreign substance stimulating antibody production; binding partner of antibody
    ADCC
    Antibody-dependent cellmediated cytotoxicity; a mechanism of cell-mediated immunity whereby an effector cell of the immune system actively destroys a target cell that has been bound by specific antibodies
    ADCP
    Antibody dependent cellular phagocytosis
    ALL
    Acute lymphoblastic leukemia; a form of cancer of the white blood cells characterized by excess lymphoblasts
    Antibody
    Proteins of the immune system that recognize antigens, thereby triggering an immune response
    Antibody library
    A collection of genes that encode corresponding human antibodies
    Autoimmune disease
    Disease caused by an immune response by the body against one of its own tissues, cells or molecules
  2. B

    Biosimilars
    Term used to describe officially approved new versions of innovator biopharmaceutical products, following patent expiry
    Bispecific
    Antibody consisting of parts from two different antibodies
    BiTE
    a class of artificial bispecific monoclonal antibodies that are investigated for the use as anti-cancer drugs by directing the T cells’ cytotoxic activity against cancer cells. BiTE® is a registered trademark of Micromet AG
  3. C

    CAGR
    Compound annual growth rate
    Cash flow
    Key performance indicator in the cash flow statement used to assess the financial and earning capacity
    CD19
    Therapeutic target for the treatment of B-cell lymphomas and leukemias
    CD20
    Therapeutic target for the treatment of B-cell lymphomas and leukemias
    CD38
    Therapeutic target for the treatment of multiple myeloma and certain leukemias
    Clinical trial
    Clinical trials allow safety and efficacy data to be collected for new drugs or devices. Depending on the type of product and the stage of its development, investigators enroll healthy volunteers and/or patients into small pilot studies initially, followed by larger-scale studies in patients
    CLL
    Chronic lymphocytic leukemia; most common type of cancer of the blood and bone marrow, affecting the B-cells
    CMO
    Contract Manufacturing Organization
    CRO
    Contract Research Organization
    CTO
    Contract Testing Organization
  4. E

    EMEA
    European Medicines Agency
  5. F

    Fc-engineered
    Modification within the Fc part of an antibody to improve effector function
    Fc-part
    Constant part of an antibody known as the Fc (Fragment, crystallizable) region
    FDA
    Food and Drug Administration; US federal agency for the supervision of food and drugs
  6. G

    GCP
    Good clinical practice; an international ethical and scientific quality standard for designing, conducting, recording and reporting trials that involve the participation of human subjects
    GLP
    Good laboratory practice; a formal framework for the implementation of safety tests on chemical products
    GM-CSF
    Granulozyte-macrophage colony-stimulating factor; underlying target molecule of MOR103 program
    GMP
    Good management practice; term for the control and management of manufacturing and quality control testing of pharmaceutical products and medical devices
  7. H

    HGB
    German accounting standards
    HuCAL
    Human Combinatorial Antibody Library. Proprietary antibody library enabling rapid generation of specific human antibodies for all applications (explanation of GOLD/Platinum)
    Human
    Of human origin
  8. I

    Inclusion Body Myositis
    Inflammatory myopathy
    Inflammatory diseases
    Inflammatory tissue modification, often caused by autoimmune reactions
    Innovation capital
    Investments in start-ups with technologies and product candidates being close to MorphoSys’s areas of interest
    in vitro
    In a test tube
    in vivo
    In a living organism
  9. L

    Lantipeptides
    Novel class of therapeutics with high target selectivity and improved drug-like properties
    Life sciences
    All branches of science that study all organisms, especially living ones
  10. M

    Market capitalization
    Value of a company’s outstanding shares, as measured by shares times current price
    market capitalization
    Value of a company’s outstanding shares, as measured by shares times current price
    M&A
    Mergers & Acquisitions
    Monoclonal antibody
    Homogeneous antibody originating from a single clone, produced by hybridoma cell
    MRSA
    Methicillin-resistant Staphylococcus aureus; type of bacteria that is resistant to certain antibiotics and causing severe infections; occurs most frequently among patients in healthcare settings
    Multiple myeloma
    Type of cancer that develops in a subset of white blood cells called plasma cells formed in the bone marrow
    Multiple sclerosis
    Disease of the central nervous system characterized by the destruction of nerve fibers
  11. N

    NHL
    Non-Hodgkin lymphomas; diverse group of blood cancers that include any kind of lymphoma except Hodgkin’s lymphomas
  12. P

    Pharmacodynamics
    Study of the effects of drugs on the body
    Pharmacokinetics
    Determination of the fate of substances administered externally to a living organism
    Plaque psoriasis
    Most common form of psoriasis, a chronic, non-contagious autoimmune disease which affects the skin and joints
    Preclinic
    Preclinical stage of drug development; tests in animal models as well as in laboratory essays
    Protein
    Polymer consisting of amino acids, e. g. antibodies and enzymes
  13. R

    R&D
    Research and Development
    Research Reagents
    A substance used in research applications
    Rheumatoid arthritis
    Inflammatory disease of the joints; abbreviation: RA
    Royalties
    Percentage share of ownership of the revenue generated by drug products
  14. S

    Scaffolds
    Proteins with antibody - like capabilities
    Slonomics
    DNA engineering and protein library generation platform acquired by MorphoSys in 2010
    Small molecules
    Low molecular compounds
  15. T

    Target
    Target molecule for therapeutic intervention, e.g. on surface of diseased cell
    Target Product Profule (TPP)
    Summary of specifications on a planned therapeutic product
    TPP
    Target Product Profile
    TecDAX
    Index of the 30 largest technology companies listed on the Frankfurt Stock Exchange
    Toxicity
    Poisonousness
    Trifunctional antibodies
    Modified antibody binding three target structures
  16. Y

    Ylanthia
    Novel next-generation antibody platform of MorphoSys